Synthesis and Antimicrobial Screening of Novel 3, 5-Disubstituted Indazole Derivatives

Author(s): P. Padmaja, M. Yedukondalu, R. Sridhar, Siddhardha Busi, M. V. Basaveswara Rao

Journal Name: Letters in Drug Design & Discovery

Volume 10 , Issue 7 , 2013

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Amine coupling strategy was developed for the synthesis of new indazole derivatives through reaction of 4-(3- (4-hydroxyphenyl)-1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-5-yl) benzoic acid 19 with amines 20a-i. All the newly synthesized compounds were screened for their antimicrobial and antifungal activities. Among the several compounds synthesized (4-(3-(4-hydroxyphenyl)-1H-indol-5-yl)phenyl)(piperazin-1-yl)methanone 2, (4-(3-(4-hydroxyphenyl)-1Hindazol- 5-yl)phenyl)(4-methylpiperazin-1-yl)methanone 3, 1-(4-(4-(3-(4-hydroxyphenyl)-1H-indol-5-yl) benzoyl) piperazin- 1-yl) ethanone 4 and (4-(3-(4-hydroxyphenyl)-1H-indol-5-yl) phenyl)(pyrrolidin-1-yl)methanone 9 showed potential activities against a variety of bacterial and fungal strains.

Keywords: Amines, Acid and amine coupling, Antimicrobial activity, Antifungal activity, Indazole derivatives, Suzuki coupling.

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Article Details

Year: 2013
Page: [625 - 631]
Pages: 7
DOI: 10.2174/1570180811310070010
Price: $65

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