Hydrazones are important classes of compounds found in many synthetic products. Due to their importance in
synthetic chemistry, the present article reports the synthesis of twelve new hydrazone derivatives based on the coupling of
2,5-difluorobenzohydrazide with different benzaldehydes and screened for their antibacterial activities at the concentration
250 µg/mL with reference to the standard antibacterial drug Ampicillin. The screening results revealed that hydrazone
derivatives 4d, 4e, 4f and 4h having fluorine substitution showed significant antibacterial activity comparable to that of
standard drug Ampicillin.
Keywords: 2, 5-Difluoro benzoic acid, Aldehydes, Hydrazones, Antibacterial Activity, Fluorine, Gram positive.
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Published on: 21 June, 2013
Page: [620 - 624]