Abstract
Hydrazones are important classes of compounds found in many synthetic products. Due to their importance in synthetic chemistry, the present article reports the synthesis of twelve new hydrazone derivatives based on the coupling of 2,5-difluorobenzohydrazide with different benzaldehydes and screened for their antibacterial activities at the concentration 250 µg/mL with reference to the standard antibacterial drug Ampicillin. The screening results revealed that hydrazone derivatives 4d, 4e, 4f and 4h having fluorine substitution showed significant antibacterial activity comparable to that of standard drug Ampicillin.
Keywords: 2, 5-Difluoro benzoic acid, Aldehydes, Hydrazones, Antibacterial Activity, Fluorine, Gram positive.
Letters in Drug Design & Discovery
Title:Synthesis of Novel Hydrazone Derivatives of 2, 5-difluorobenzoic Acid as Potential Antibacterial Agents
Volume: 10 Issue: 7
Author(s): Rajasekhar Narisetty, K. B. Chandrasekhar, Sandeep Mohanty and B. Balram
Affiliation:
Keywords: 2, 5-Difluoro benzoic acid, Aldehydes, Hydrazones, Antibacterial Activity, Fluorine, Gram positive.
Abstract: Hydrazones are important classes of compounds found in many synthetic products. Due to their importance in synthetic chemistry, the present article reports the synthesis of twelve new hydrazone derivatives based on the coupling of 2,5-difluorobenzohydrazide with different benzaldehydes and screened for their antibacterial activities at the concentration 250 µg/mL with reference to the standard antibacterial drug Ampicillin. The screening results revealed that hydrazone derivatives 4d, 4e, 4f and 4h having fluorine substitution showed significant antibacterial activity comparable to that of standard drug Ampicillin.
Export Options
About this article
Cite this article as:
Narisetty Rajasekhar, Chandrasekhar B. K., Mohanty Sandeep and Balram B., Synthesis of Novel Hydrazone Derivatives of 2, 5-difluorobenzoic Acid as Potential Antibacterial Agents, Letters in Drug Design & Discovery 2013; 10 (7) . https://dx.doi.org/10.2174/1570180811310070009
DOI https://dx.doi.org/10.2174/1570180811310070009 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Role of Renin-Angiotensin System in Vascular Endothelial Dysfunction of Pregnancy-Induced Hypertension
Current Hypertension Reviews Effects of Insulin on the Vasculature
Current Vascular Pharmacology The Hellp Syndrome: A Review
Current Women`s Health Reviews The Endothelin Axis: A Novel Target for Pharmacotherapy of Female Malignancies
Current Vascular Pharmacology Oxidative Stress and Transforming Growth Factor-β<sub>1</sub>-induced Cardiac Fibrosis
Cardiovascular & Hematological Disorders-Drug Targets Contemporary Risk Assessment and Cardiovascular Outcomes in Peripheral Arterial Disease
Cardiovascular & Hematological Disorders-Drug Targets Editorial [Hot topic: Controversies in Hypertension Treatment (Guest Editors: Maciej Banach, Sverre E. Kjeldsen and Krzysztof Narkiewicz)]
Current Vascular Pharmacology Efficient One-pot HATU Mediated Coupling of Dicarboxylic Acid and Amines for the Synthesis of Diamide at Ambient Temperature
Letters in Organic Chemistry On the Involvement of H2S in Nitroso Signaling and Other Mechanisms of H2S Action
Current Pharmaceutical Biotechnology Recent Synthetic Strategies for Monocyclic Azole Nucleus and Its Role in Drug Discovery and Development
Current Organic Synthesis MRI findings and renal function in patients on lithium therapy
Current Drug Safety Inflammation, Adipocytokines, and Atherosclerosis in the Metabolic Syndrome
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry Biological Therapies: Effects of Proinflammatory Pathways and their Inhibition on the Myocardium of Rheumatoid Athritis Patients
Current Medicinal Chemistry Insulin, Thrombin, ERK1/2 Kinase and Vascular Smooth Muscle Cells Proliferation
Current Pharmaceutical Design COPD Management: Look Beyond the Airway Obstruction, Chronic Bronchitis and Emphysema
Current Respiratory Medicine Reviews Design of Second Generation Phosphodiesterase 5 Inhibitors
Current Topics in Medicinal Chemistry Diabetic Vasculopathy and the Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 (LOX-1)
Current Diabetes Reviews The First Line of Defense Against Cardiac Hypertrophy
Current Molecular Medicine Third and Fourth Generation Fluoroquinolone Antibacterials: A Systematic Review of Safety and Toxicity Profiles
Current Drug Safety Resveratrol and Clinical Trials: The Crossroad from In Vitro Studies to Human Evidence
Current Pharmaceutical Design