Title:Molecular Docking Studies of Novel Arylidene-2, 4-Thiazolidinediones as Potential Aldose Reductase Inhibitors
VOLUME: 10 ISSUE: 7
Author(s):Manoj Kumar Gautam and Suresh Thareja
Affiliation:Institute of Pharmaceutical Sciences, GGV (Central University), Bilaspur- 495 009 (C.G.), India.
Keywords:Diabetic complications, Diabetes, Docking, Aldose reductase, Nephropathy, Thiazolidinedione.
Abstract:Diabetes mellitus is a chronic metabolic disease affected a wide range of population all over the world and
leads to development of many severe long term complications. Aldose reductase (AR) is the enzyme considered to play a
key role in the development of secondary diabetic complications via polyol pathway. AR inhibition has been proposed as
a strategy to prevent and delayed such complications. 2,4-thiazolidinedione derivatives being isosteres of hydantoin,
emerged as potential AR inhibitors with antidiabetic activity. Therefore, we have designed novel arylidene-2,
4-thiazolidinediones as AR inhibitors using molecular docking technique. Mol-dock score along with re-rank score was
the criteria for measuring the affinity of STMG-(1-40) with the AR enzymes. Result of present study will provide a new
guideline for the further design of novel potent inhibitors of AR in the management of diabetes along with its
complications.
