A series of novel hybrid compounds between tricyclic indeno[5,6-b]furan and imidazole has been prepared and
evaluated in vitro against a panel of human tumor cell lines. The results suggest that the existence of benzimidazole ring
and substitution of the imidazolyl-3-position with a naphthylacyl group were vital for modulating cytotoxic activity. In
particular, hybrid compound 26 was found to be the most potent compound against 5 strains human tumor cell lines and
more active than cisplatin (DDP), while compound 18 was more selective towards breast carcinoma (MCF-7) and colon
carcinoma (SW480) with IC50 value 3.4-fold and 4.3-fold more sensitive to DDP.
Keywords: Hybrid compound, Imidazole, Indeno[5, 6-b]furan, Synthesis, Cytotoxic activity, Structure–activity relationships.
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