Selectivity, Binding Affinity, and Ionization State of Matrix Metalloproteinase Inhibitors

Author(s): Haizhen A. Zhong, Jack Arbiser, J. Phillip Bowen

Journal Name: Current Pharmaceutical Design

Volume 19 , Issue 26 , 2013

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Abstract:

This review highlights some recent advances in the design and development of matrix metalloproteinase inhibitors, especially those targeting MMP-2, MMP-9, and MMP-13. Various zinc-binding groups and non-zinc-binding groups are discussed. Interactions between residues in the critical S1' specificity pocket and MMP inhibitors are given special attention. The influence of ionization states of hydroxamates and retrohydroxamates on the docking outcome and the presence of zinc ions in the active site are explored in light of enhancing enrichment factors for docking studies. Details are given to structural factors for the development of more selective and more potent MMP inhibitors.

Keywords: MMP-2, MMP-3, MMP-13, rheumatoid arthritis, osteoarthritis, cancer, docking, and zinc binding group.

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Article Details

VOLUME: 19
ISSUE: 26
Year: 2013
Page: [4701 - 4713]
Pages: 13
DOI: 10.2174/1381612811319260004
Price: $65

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