Abstract
Peripheral arterial disease (PAD) is due to diffuse atherosclerosis. The pathological process is characterized mainly by the aberrant proliferation of vascular smooth muscle cells and the formation of neointimal lesions. MicroRNAs (miRNAs) are highly conserved non-coding small RNA molecules that regulate a large fraction of the genome by binding to complementary mRNA sequences, resulting in post-transcriptional gene silencing. Recent evidence has demonstrated that specific miRNAs are involved in the pathological development of PAD. In this review, the roles of specific miRNAs in PAD are summarized.
Keywords: MicroRNAs, peripheral arterial disease, angiogenesis.
Current Topics in Medicinal Chemistry
Title:MicroRNAs in Peripheral Artery Disease
Volume: 13 Issue: 13
Author(s): Toshio Imanishi and Takashi Akasaka
Affiliation:
Keywords: MicroRNAs, peripheral arterial disease, angiogenesis.
Abstract: Peripheral arterial disease (PAD) is due to diffuse atherosclerosis. The pathological process is characterized mainly by the aberrant proliferation of vascular smooth muscle cells and the formation of neointimal lesions. MicroRNAs (miRNAs) are highly conserved non-coding small RNA molecules that regulate a large fraction of the genome by binding to complementary mRNA sequences, resulting in post-transcriptional gene silencing. Recent evidence has demonstrated that specific miRNAs are involved in the pathological development of PAD. In this review, the roles of specific miRNAs in PAD are summarized.
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Cite this article as:
Imanishi Toshio and Akasaka Takashi, MicroRNAs in Peripheral Artery Disease, Current Topics in Medicinal Chemistry 2013; 13 (13) . https://dx.doi.org/10.2174/15680266113139990107
DOI https://dx.doi.org/10.2174/15680266113139990107 |
Print ISSN 1568-0266 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4294 |
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