Diabetes mellitus (DM) is a complex metabolic disorder characterized by low insulin production/secretion by
pancreatic beta cells and/or low responsiveness by insulin target tissues MicroRNAs have been associated with DM, but it
is not clear whether this is a cause or an effect of metabolic abnormalities related to DM. In the hyperglycemic environment
miRNAs are in involved in multiple stages of cardiovascular disease development and progression. In diabetic patients
with cardiovascular disease miRNAs could potentially serve as early biomarkers for diagnosis and as therapeutic
agents. The current review focuses on the involvement of miRNAs in molecular mechanisms underlying the pathogenesis
of DM and its cardiovascular complications.
Keywords: miRNAS, diabetes mellitus, cardiovascular disease.
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Published on: 31 May, 2013
Page: [1533 - 1539]