One criterion of green chemistry is efficiency that may be fulfilled by selecting atomic efficient reactions, and
among others, utilizing the microwave (MW) or the phase transfer catalytic techniques, rationalizing the use of solvents
and optimizing the syntheses. The use of green chemical tools is exemplified via a wide range of organophosphorus reactions
including additions/cycloadditions (Michael additions, carbonyl additions and Diels-Alder cycloadditions), substitutions/
couplings (acylations, alkylations, the Arbuzov reaction) and 3-component condensations (the Kabachnik–Fields reaction).
An efficient optimization is shown via the synthesis of dronic acids or their sodium salt (dronates) from substituted
acetic acid derivatives and tervalent P-reactants (PCl3 and P(OH)3). The optimum conditions were explored on a rational