Abstract
Recently the relationship between oxidative stress and aging has been brought into question. It has been suggested that while oxidative events may play a role in the progression of age-related pathologies, it is not relevant to aging processes not involving specific diseases associated with senescence. The evidence in support of this concept is largely based on studies with the roundworm, Caenorhabditis elegans (C. elegans) that has been extensively used as a model system to study aging. This commentary evaluates data derived from C. elegans and documents that the preponderance of evidence from this species supports the role of pro-oxidant events as being a significant contributor to normal aging. Possible reasons for some anomalous findings conflicting with this concept, are discussed.
Keywords: Antioxidants, aging, Caenorhabditis elegans, lifespan, oxidative stress, superoxide.
Current Aging Science
Title:Evaluation of Role of Oxidative Stress on Aging in Caenorhabditis elegans: A Brief Review
Volume: 6 Issue: 3
Author(s): Kedar N. Prasad and Stephen C. Bondy
Affiliation:
Keywords: Antioxidants, aging, Caenorhabditis elegans, lifespan, oxidative stress, superoxide.
Abstract: Recently the relationship between oxidative stress and aging has been brought into question. It has been suggested that while oxidative events may play a role in the progression of age-related pathologies, it is not relevant to aging processes not involving specific diseases associated with senescence. The evidence in support of this concept is largely based on studies with the roundworm, Caenorhabditis elegans (C. elegans) that has been extensively used as a model system to study aging. This commentary evaluates data derived from C. elegans and documents that the preponderance of evidence from this species supports the role of pro-oxidant events as being a significant contributor to normal aging. Possible reasons for some anomalous findings conflicting with this concept, are discussed.
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Cite this article as:
Prasad N. Kedar and Bondy C. Stephen, Evaluation of Role of Oxidative Stress on Aging in Caenorhabditis elegans: A Brief Review, Current Aging Science 2013; 6 (3) . https://dx.doi.org/10.2174/18746098112059990031
DOI https://dx.doi.org/10.2174/18746098112059990031 |
Print ISSN 1874-6098 |
Publisher Name Bentham Science Publisher |
Online ISSN 1874-6128 |
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