Clomiphene Citrate, Metformin or Both for Ovulation Induction in Therapy Naïve Women with Polycystic Ovary Syndrome (PCOS)? A Descriptive Review

Author(s): Stefano Palomba, Angela Falbo, Giovanni B. La Sala

Journal Name: Current Drug Therapy

Volume 8 , Issue 1 , 2013

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Background: Early treatment for infertile women with polycystic ovary syndrome (PCOS) is likely crucial and includes mainly clomiphene citrate (CC) and metformin.

Objectives: To review the literature data regarding the use of CC, metformin, or both for the treatment of infertility in anovulatory patients with PCOS.

Materials and Methods: Using PubMed database, all main relevant articles studying therapy naïve patients with PCOS who received CC, metformin or both were searched, reviewed and analyzed.

Main Results and Conclusions: In infertile obese PCOS patients, CC is the therapy of choice for inducing ovulation. Combining CC and metformin is not more effective than CC alone. Further studies are needed to define the best first line treatment in non-obese PCOS patients.

Keywords: Clomiphene citrate, infertility, metformin, ovulation induction, PCOS, review, sterility, treatment.

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Article Details

Year: 2013
Published on: 31 May, 2013
Page: [30 - 37]
Pages: 8
DOI: 10.2174/1574885511308010004

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