Chemometric Assisted Simultaneous Analysis of Verapamil Hydrochloride, Gliclazide and Simvastatin in Bulk Drug and Fixed Dose Combinatinos (polypill) - A Futuristic Approach

Author(s): Rahul Bhaskar, Radhika Bhaskar, Mahendra K. Sagar, Vipin Saini, Krishnamoorthy Bhat

Journal Name: Current Analytical Chemistry

Volume 10 , Issue 4 , 2014

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Graphical Abstract:


In this study, the simultaneous determination of verapamil hydrochloride, gliclazide and simvastatin in pharmaceuticals by chemometric approaches using UV spectrophotometry has been reported. Spectra of verapamil hydrochloride, gliclazide and simvastatin were recorded at several concentrations within their linear ranges and were used to compute the calibration mixture between wavelength range of 200 and 400 nm at an interval of 3 nm in pH 6.8 phosphate buffer containing 0.5% sodium lauryl sulphate (SLS). Partial least squares regression (PLS) and principle component regression (PCR) were used for chemometric analysis of the data. The analytical performances of these chemometric methods were characterized by relative prediction errors and recoveries (%) and were compared with each other. These two methods were successfully applied to pharmaceutical formulation, tablet, with no interference from excipients as indicated by the recovery study results. The proposed methods are simple, rapid and can be easily used as an alternative analysis tool in the quality control of drugs and formulation.

Keywords: Partial least square, principle component regression, verapamil hydrochloride, gliclazide, simvastatin, multivariate analysis.

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Article Details

Year: 2014
Published on: 01 July, 2014
Page: [545 - 551]
Pages: 7
DOI: 10.2174/15734110113090990025
Price: $65

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