Mechanisms, Prevention and Treatment of Distal Embolization

Author(s): Italo Porto, Giovanni Luigi De Maria, Maurizio Pieroni, Leonardo Bolognese, Filippo Crea

Journal Name: Current Pharmaceutical Design

Volume 19 , Issue 25 , 2013

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Distal embolization (DE) can be either spontaneous or iatrogenic, occurring during percutaneous coronary intervention (PCI). The nature, composition and biochemical properties of embolized material differ according to the setting in which DE occurs: acute coronary syndromes (ACS) or stable coronary artery disease (CAD). DE occurrence is related to increased cardiac biomarkers, negative left ventricular remodeling and associated with a poor prognosis. Prevention and treatment of DE represent some of the most debated topics in interventional cardiology. This review paper is focused on mechanisms of DE and on the strategies for its prevention and treatment in both ACS and stable CAD.

Keywords: Distal embolization, microvascular obstruction, thrombus aspiration, protection devices, antiplatelet agents.

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Article Details

Year: 2013
Page: [4576 - 4585]
Pages: 10
DOI: 10.2174/1381612811319250006
Price: $65

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PDF: 17