Ageing as a Trait de Union Between Diabetes and Dementia for Frailty

Author(s): Roberta Semprini, Mauro Ragonese, Maurizio Poggi, Antonella Franze, Alessandro Martorana

Journal Name: CNS & Neurological Disorders - Drug Targets
(Formerly Current Drug Targets - CNS & Neurological Disorders)

Volume 12 , Issue 4 , 2013

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A frail patient is one who carries a sum of poly-pathologies, whose co-existence may shorten his life expectation. Diabetes mellitus type 2 and metabolic syndrome play a substantial role in it, but dementia has increasingly risen in importance. Interestingly, the insulin pathway was suggested to be responsible for the metabolic cascade that leads to amyloid-beta deposit and pathology. Nevertheless, a clear relationship between them was just experimentally, rather than clinically demonstrated. In this work the authors suggest a possible link between insulin, diabetes and Alzheimer’s disease, whose co-existence could be responsible for physical and cognitive decline but not for frailty. We suggest that these factors could be responsible for frailty only if senescence-associated.

Keywords: Alzheimer’s disease, diabetes mellitus type 2, insulin, amyloid β-peptide42, tau.

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Article Details

Year: 2013
Page: [520 - 524]
Pages: 5
DOI: 10.2174/1871527311312040012
Price: $65

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