Enantiomerically pure product synthesis plays a key role in production of pharmaceuticals. The application of
biocatalytic approaches represents a convenient and sustainable way for this purpose. The enormous potential of enzymes
for the transformation of synthetic chemicals with high chemo-, regio- and enantioselectivity is on increasing awareness.
In particular, lipases show a high versatility to recognize non-natural substrates being successfully applied in regio- and
stereoselective biotransformations. The immobilization technology on lipases is not only a requisite for the industrial implementation
but it has been a great methodology to alter their catalytic properties to obtain highly enantio- and regioselective
biocatalysts in the enantioselective synthesis of chiral drugs or drug intermediates. This review focuses on showing
some of the latest advances on the use of immobilized lipases on pharmaceutical biotransformations.
Keywords: Lipases, kinetic resolution, asymmetric transformation, chemical modification, immobilization, pharmaceuticals,
Rights & PermissionsPrintExport
Published on: 31 May, 2013
Page: [113 - 136]