Oxindole derivatives 3-25 have been synthesized from commercially available oxindole by refluxing with different
aromatic aldehydes in good yields. Their in vitro antiglycation potential has been evaluated. They showed a varying
degree of antiglycation activity with IC50 values ranging between 150.4 - 856.7 µM. 3-[(3-Chlorophenyl)methylidene]-
1,3-dihydro-2H-indol-2-one (IC50 = 150.4 ± 2.5 µM) is the most active compound among the series, better than the standard
rutin with an IC50 value 294.5 ± 1.50 µM. The structures of the compounds were elucidated by 1H-NMR and mass
spectroscopy and elemental analysis. A limited structure-activity relationship has been developed.
Keywords: Oxindole, benzaldehydes, antiglycation, rutin, AGEPs.
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