One-Pot Synthesis of Novel Spiro[quinazoline/pyrimidine]ones via Multi Component Reaction

Author(s): Gangadhar Meshram, Pramod Wagh, Shruti Deshpande, Vipul Amratlal

Journal Name: Letters in Organic Chemistry

Volume 10 , Issue 6 , 2013


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Abstract:

A new and facile one-pot synthesis of the biologically important spiro[quinazoline/pyrimidine]ones scaffold was synthesized simply by the reaction of isatin, 1,3-dione and urea or thiourea. The scope of the reaction was successfully extended by employing two other reactive ketones (acenaphthylene-1,2-dione and ninhydrin) instead of isatin. A series of new spiro cyclic derivatives via multi-component reaction was obtained by using guanidine and employing different 1,3 - dicarbonyl compounds.

Keywords: Acenaphthylene-1, 2-dione, 1, 3-Dicarbonyls, dihydropyrimidinone, isatin, multi-component reaction, ninhydrin, spiroheterocycles.

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Article Details

VOLUME: 10
ISSUE: 6
Year: 2013
Published on: 31 May, 2013
Page: [445 - 450]
Pages: 6
DOI: 10.2174/1570178611310060006
Price: $65

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