The development of more effective antithrombotic agents with reduced side risk is necessary for the prevention
of thromboembolic events. In recent years, bioactive peptides derived from food proteins have received considerable attention
because of their numerous healths beneficial. Based on their amino acids sequences these peptides can exhibit
various biological activities including, antihypertensive, antioxidative and antibacterial activities. Moreover, several naturally
or food proteins-derived bioactive peptides that could prolong the activated partial thromboplastin time (APTT) and
thrombin time (TT) have been isolated. Due to their therapeutic potential in the treatment or prevention of various diseases,
bioactive peptides can be used as functional food ingredients, nutraceuticals or pharmaceuticals.
Marine organisms represent a valuable source of new bioactive substances including bioactive peptides. This paper presents
an overview of the bioactive anticoagulant peptides derived from fish protein sources, as well as the enzymatic proteolysis
approach used for the development of these new biopeptides.