From Gastroprotective to Ulcerogenic Effects of Glucocorticoids: Role of Long-Term Glucocorticoid Action

Author(s): Ludmila Filaretova, Tatiana Podvigina, Tatiana Bagaeva, Olga Morozova

Journal Name: Current Pharmaceutical Design

Volume 20 , Issue 7 , 2014

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Abstract:

Glucocorticoids may have dual action on the gastric mucosa: gastroprotective and ulcerogenic. In this article, we review the data which suggested that an initial action of endogenous glucocorticoids, including stress-produced ones as well as exogenous glucocorticoids is gastroprotective and consider possible mechanisms of the conversion of physiological gastroprotective action of glucocorticoid hormones to their pathological ulcerogenic effect.

Keywords: The hypothalamic-pituitary-adrenocortical axis, glucocorticoids, dexamethasone, gastric mucosa, stress, indomethacin, injury, gastroprotection.

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Article Details

VOLUME: 20
ISSUE: 7
Year: 2014
Page: [1045 - 1050]
Pages: 6
DOI: 10.2174/13816128113199990419
Price: $65

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