Glucocorticoids may have dual action on the gastric mucosa: gastroprotective and ulcerogenic. In this article, we review the
data which suggested that an initial action of endogenous glucocorticoids, including stress-produced ones as well as exogenous glucocorticoids
is gastroprotective and consider possible mechanisms of the conversion of physiological gastroprotective action of glucocorticoid
hormones to their pathological ulcerogenic effect.
Keywords: The hypothalamic-pituitary-adrenocortical axis, glucocorticoids, dexamethasone, gastric mucosa, stress, indomethacin, injury,
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