Hypoxia-inducible factor (HIF)-1α is over-expressed in hepatocellular carcinoma (HCC) and degraded by
ubiquitin-proteasome pathways under normoxic conditions. Hepatocyte hypoxia enhances proliferation, angiogenesis,
metastasis, chemoresistance, and radioresistance of HCC. The importance role of HIF-1α expression in HCC may
improve the prognostic and therapeutic technique. This article reviews the HIF-1α expression and its gene during the rat
HCC development, the level of HIF-1α expression in HCC patients, and the effect of silencing HIF-1α gene by miRNA on
inhibition of HepG2 cell proliferation.
Keywords: Hepatocellular carcinoma, hypoxia-inducible factor-1alpha, vascular endothelial growth factor, angiopoietin-2, and
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