Hypoxia-inducible Factor-1alpha: Molecular-targeted Therapy for Hepatocellular Carcinoma

Author(s): Z. Z. Dong, M. Yao, L. Wang, W. Wu, X. Gu, D. F. Yao

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 13 , Issue 9 , 2013

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Hypoxia-inducible factor (HIF)-1α is over-expressed in hepatocellular carcinoma (HCC) and degraded by ubiquitin-proteasome pathways under normoxic conditions. Hepatocyte hypoxia enhances proliferation, angiogenesis, metastasis, chemoresistance, and radioresistance of HCC. The importance role of HIF-1α expression in HCC may improve the prognostic and therapeutic technique. This article reviews the HIF-1α expression and its gene during the rat HCC development, the level of HIF-1α expression in HCC patients, and the effect of silencing HIF-1α gene by miRNA on inhibition of HepG2 cell proliferation.

Keywords: Hepatocellular carcinoma, hypoxia-inducible factor-1alpha, vascular endothelial growth factor, angiopoietin-2, and molecular-targeted therapy.

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Article Details

Year: 2013
Page: [1295 - 1304]
Pages: 10
DOI: 10.2174/1389557511313090004
Price: $65

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