Research on regulation of cellulases and hemicellulases gene expression may be very useful for increasing the
production of these enzymes in their native producers. Mechanisms of gene regulation of cellulase and hemicellulase expression
in filamentous fungi have been studied, mainly in Aspergillus and Trichoderma. The production of these extracellular
enzymes is an energy-consuming process, so the enzymes are produced only under conditions in which the
fungus needs to use plant polymers as an energy and carbon source. Moreover, production of many of these enzymes is
coordinately regulated, and induced in the presence of the substrate polymers. In addition to induction by mono- and
oligo-saccharides, genes encoding hydrolytic enzymes involved in plant cell wall deconstruction in filamentous fungi can
be repressed during growth in the presence of easily metabolizable carbon sources, such as glucose. Carbon catabolite repression
is an important mechanism to repress the production of plant cell wall degrading enzymes during growth on preferred
carbon sources. This manuscript reviews the recent advancements in elucidation of molecular mechanisms responsible
for regulation of expression of cellulase and hemicellulase genes in fungi.
Keywords: Cellulase, Cellulose, CRE1, Hemicellulase, Sophorose, Xylan, XYR1.
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Published on: 31 May, 2013
Page: [230 - 249]