Synthetic Approaches Towards the Marine Alkyl Purines

Author(s): M. Gordaliza, P. G. Baraldi

Journal Name: Current Medicinal Chemistry

Volume 20 , Issue 22 , 2013

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Agelasines, asmarines and related compounds are natural products with a hybrid terpene-purine structure isolated from numerous genera of sponges (Agela sp, Raspailia sp). Nuttingins and malonganenones are tetraprenylated purine alkaloids from gordonian (Eplexura sp, Leptogorgia sp). Some of these alkaloids displayed broad spectrum activity including cytotoxic activity against several cancer cells. The review summarizes the synthesis of mono- or bi-cyclic diterpenoids usually having a 9-methyladenine moiety.

Keywords: Alkyl purine, terpene purine, agelasine, ageline, ageloxime, gelasine, agelasimine, asmarine, nuttingin, malonganenone.

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Article Details

Year: 2013
Page: [2798 - 2811]
Pages: 14
DOI: 10.2174/0929867311320220005
Price: $65

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