Role of Descending Aminergic Pathways in the Development of Locomotion

Author(s): Edouard Pearlstein

Journal Name: Current Pharmaceutical Design

Volume 19 , Issue 24 , 2013


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Abstract:

The development of locomotor function in terrestrial higher vertebrates takes place during both the embryonic period and the first days (or weeks, depending on the species) of postnatal life. It relies on the maturation of different elements such as musculoskeletal system, sensory systems, network connectivity, and neuronal intrinsic properties. This maturation results from the interplay between genetic determinants and activity dependent processes. Numerous studies have shown that aminergic (serotonin, noradrenaline, dopamine) projections to the spinal cord could contribute to the maturation of locomotor networks. In this review we will describe the development of aminergic projections in the spinal cord of higher terrestrial vertebrates, and we will review literature describing the trophic role played by these pathways on different parameters of locomotor function.

Keywords: Serotonin, noradrenaline, dopamine, locomotion, central pattern generator, neonatal development, embryonic development, mice, rats, chicken.

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Article Details

VOLUME: 19
ISSUE: 24
Year: 2013
Published on: 31 May, 2013
Page: [4332 - 4340]
Pages: 9
DOI: 10.2174/1381612811319240002
Price: $65

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