The epithelial sodium channel (ENaC) plays an essential role in transepithelial sodium reabsorption in the renal
connecting tubule and collecting duct. Therefore, controlling ENaC activity is an important regulatory event in electrolyte
and extracellular volume homeostasis, and thus in the control of blood pressure. Many independent signaling pathways
converge on ENaC, although the most important for its physiological role is the enhancement of channel activity by the
steroid hormone aldosterone. In this review, we briefly summarize current knowledge about ENaC regulation and the different
chemical compounds available to directly or indirectly modify channel function. In addition, current and possible
clinical uses of ENaC and aldosterone antagonists are highlighted.