Exploring the Unexplored Practical and Alternative Synthesis of 3- (Trifluoromethyl)-Triazolopiperazine the Key Intermediate for Sitagliptin

Author(s): Lakshmikant H. Nitlikar, Sunil N. Darandale, Devanand B. Shinde

Journal Name: Letters in Organic Chemistry

Volume 10 , Issue 5 , 2013

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The practical synthesis of 3-(trifluoromethyl)-triazolopiperazine the key intermediate of Sitagliptin and 3- (trifluoromethyl)-triazolopyridine was carried out employing industrially feasible transformations. The other advantage of this method is the new environment friendly approach to synthesize triazolopiperazine and triazolopyridines by eliminating the commonly used trifluoroacetic anhydride and polyphosphoric acid.

Keywords: Sitagliptin, 3-(trifluoromethyl)-triazolopiperazine, 3-(trifluoromethyl)-triazolopyridine, antidiabetic.

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Article Details

Year: 2013
Published on: 23 May, 2013
Page: [348 - 352]
Pages: 5
DOI: 10.2174/1570178611310050008
Price: $65

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