Title:Baicalein-Phospholipid Complex: A Novel Drug Delivery Technology for Phytotherapeutics
VOLUME: 10 ISSUE: 3
Author(s):Devendra Singh Rawat, Bandana K. Thakur, Mona Semalty, Ajay Semalty, Prabhakar Badoni and Mohan Singh Maniyari Rawat
Affiliation:Department of Chemistry, H.N. B. Garhwal University, Srinagar Garhwal, Uttarakhand 246174, India.
Keywords:Baicalein, differential scanning calorimetry, FT-IR, phosphatidylcholine, scanning electron microscopy, solubility
behavior and controlled release, X-RPD.
Abstract:Flavonoids are a group of low-molecular-weight polyphenolic compounds of plant origin. They exhibit a variety
of biological activities such as anti-inflammatory, antioxidant, antiviral, and antitumor etc. Baicalein, is a bioactive
flavone constituent of Scutellariae radix with a wide range of beneficial activities. But the poor solubility and dissolution
rate limit its oral intestinal absorption and bioavailability. The aim of this study was to develop an amphiphilic phytophospholipid
complex in order to enhance the delivery of poorly soluble drug (baicalein). The baicalein-phospholipid
complex (Ba-PLc) was prepared and evaluated for various physico-chemical parameters like drug loading, infrared absorption
(FT-IR), differential scanning calorimetry (DSC), X-ray powder diffractometry (X-RPD), scanning electron microscopy
(SEM), aqueous/ n-octanol solubility and dissolution study. In the SEM, phospholipid complex (Ba-PLc) was
found fluffy and porous with rough surface morphology. FT-IR, DSC and X-RPD data confirmed the formation of phospholipid
complex. The water/ n-octanol solubility of baicalein was improved significantly in the complex. Improved dissolution
was shown by the phospholipid complex. The results of the study concluded that the phospholipid complex may
be considered as a promising drug delivery system for improving the absorption and overall bioavailability of the baicalein
molecule.
