A collection of both commercial and non-commercial galloyl derivatives (either isolated from plants
or synthesized) was examined for an in vitro structure-activity relationship (SAR) screening of their anti-yeast activity.
Most of the compounds exhibited an antimycotic activity when used together with amphotericin B (AMB) and none
when used alone. The SAR study indicated the presence of two galloyl moieties in adjacent position as an important
structural characteristic. In fact, among the compounds tested, 2,3-O-digalloyl-O-methylglucose and 2,3-O-digalloyl-Omethylmannose
exhibited a synergistic interaction with AMB against a set of Candida albicans, Candida glabrata and
Pichia kudriavzevii strains. A similar biological activity has also been observed for epigallocatechin gallate (EGCG). The
high structural similarity between the two digalloyl derivatives and EGCG was advocated as possible rationale to explain
their synergy with AMB.
Keywords: Anti-yeast activity, FIC, gallic acid, glucogalloy derivatives, MIC, SAR, synergy.
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Published on: 30 April, 2013
Page: [131 - 139]