Spectral Features and In Vitro Antioxidant Study of Nanoscale Solid Dispersions of Different Sizes of Coenzyme Q10 (CoQ10) Prepared by Heat Melt and High-pressure Homogenization Method

Author(s): Yunlong Ge, Xiuhua Zhao, Song Wang, Yuangang Zu, Qingyong Li, Mei Sang, Xiaoyu Sui, Kunlun Wang

Journal Name: Current Nanoscience

Volume 10 , Issue 2 , 2014

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Coenzyme Q10 (CoQ10) has been reported as a powerful antioxidant in plasma. Recent in vivo investigations showed that cosmetically applied CoQ10 can reduce photo-aging. However, CoQ10 was barely satisfactory in topical drug delivery because of its poor solubility and high molecular weight. To improve the anti-oxidative efficiency of CoQ10 in skin photo-aging, a novel water-soluble nanoscale solid dispersion of CoQ10 (CoQ10-SD) was prepared by heat melt and high-pressure homogenization method in the present study. Three sizes of CoQ10-SDs were obtained and characterized. The spectral investigations showed that the smaller particle size solution of CoQ10-SD was more effective against ultraviolet (UV) radiation. The UVB radiation absorption and reflection of the CoQ10-SD solution increased with increasing concentration and decreasing particle size. The in vitro antioxidants of CoQ10-SD were also assessed. The results showed that, smaller particle size results in higher antioxidant effect. A lower level of intracellular reactive oxygen species was found when the myocardial cells were treated with CoQ10-SD of smaller size. These ndings indicated that CoQ10-SD can be an effective cosmetic delivery system to protect the skin from early aging induced by UV.

Keywords: Antioxidant study, coenzyme Q10, nanoparticles, solid dispersion, UV protective.

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Article Details

Year: 2014
Published on: 12 March, 2014
Page: [292 - 296]
Pages: 5
DOI: 10.2174/15734137113099990055
Price: $65

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