RNAi in Plasmodium

Author(s): Ann-Kristin Mueller, Christiane Hammerschmidt-Kamper, Annette Kaiser

Journal Name: Current Pharmaceutical Design

Volume 20 , Issue 2 , 2014

Become EABM
Become Reviewer


RNA interference (RNAi) has quickly proven to be an immensely useful tool for studying gene function and validation of potential drug targets in almost all organisms that possess the required set of proteins of the interference pathway. In protozoan parasites like Plasmodium, Toxoplasma, Entamoeba, Giardia, Trypanosoma, and Leishmania, this set of enzymes is represented divergently. Hitherto, no RNAi-related genes like Dicer and Argonaute have been identified in Plasmodium and Leishmania species, respectively. However, non-canonical RNAi-related pathways might be present in both parasites, as it has been recently demonstrated in Plasmodium.

In this review, we discuss existing challenges and future directions for developing RNAi as a tool for studying gene function and as a possible clinical application against Plasmodium.

Keywords: RNAi, Plasmodium, siRNA, clinical development, gene function.

Rights & PermissionsPrintExport Cite as

Article Details

Year: 2014
Page: [278 - 283]
Pages: 6
DOI: 10.2174/13816128113199990027

Article Metrics

PDF: 102