Recent Trends and Future Prospects in Computational GPCR Drug Discovery: From Virtual Screening to Polypharmacology

Author(s): Antonio Carrieri, Violeta I. Perez- Nueno, Giovanni Lentini, David W. Ritchie

Journal Name: Current Topics in Medicinal Chemistry

Volume 13 , Issue 9 , 2013

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Extending virtual screening approaches to deal with multi-target drug design and polypharmacology is an increasingly important aspect in drug design. In light of this, the concept of accessible chemical space and its exploration should be reviewed. The great advantages of re-using drugs with safe pharmacological profiles with favourable pharmacokinetic properties highlights drug repositioning as a valid alternative to rational drug design, massive drug development efforts, and high-throughput screening, especially when supported by in silico techniques. Here, we discuss some of the advantages of multi-target approaches, and we review some significant examples of their application in the last decade to that well known class of pharmaceutical targets, the G-protein coupled receptors.

Keywords: G-Protein coupled receptors, Multi-target drug design, Polypharmacology, Virtual screening.

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Article Details

Year: 2013
Published on: 19 May, 2013
Page: [1069 - 1097]
Pages: 29
DOI: 10.2174/15680266113139990028
Price: $65

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