Mushrooms have been consumed for their health benefits for thousands of years in China, and the main active component was
recently identified as beta-glucan. The immune-stimulating effect of beta-glucans has been well studied, and several beta-glucan
receptors have been identified on the surface of immune cells. In addition, mushroom extracts with high levels of beta-glucans have also
been shown to have direct cytotoxic effects on cancer cells, and beta-glucans are used for the treatment of cancer. This review
summarizes the use of beta-glucans in colon cancer. Evidence has supported the idea that beta-glucans can decrease the size of
xenografted colon cancer tumors via the stimulation of the immune system and direct cytotoxicity. Beta-glucans can also have synergistic
effects with chemotherapeutic agents and other immune stimulators, and an innovative strategy is to use beta-glucans to deliver
nanoparticles containing chemotherapeutic agents to the site of the colon cancer and, thus, improve the therapeutic efficacy.