All common contributing factors to epilepsy such as trauma, malignancies and infections are accompanied by different levels
of central nervous system inflammation that in turn have been associated with the occurrence of seizure. Emerging data from human
brain tissue and experimental models of epilepsy support the proposed involvement of inflammation in epilepsy. Key mediators of this
process include, among others: interleukin (IL) -1β, IL-6, tumor necrosis factor-α, adhesion molecules and component of complement.
Recent advances suggest the involvement of specific inflammatory pathways in the pathogenesis of seizures in patients with pharmacoresistant
temporal lobe epilepsy, highlighting the potential for new therapeutic strategies. This review provides an overview of the current
knowledge on the relationship between inflammatory mediators and epilepsy. We also describe experimental and clinical evidence of inflammation
in epilepsy with special emphasis on clinical aspects once the epileptogenic focus has been resected. Further insight into the
complex role of inflammation in epileptogenesis may provide new treatment options.
Keywords: Epilepsy, inflammatory mediators, IL-1β, IL-6, TNF-α, neuroinflammation, temporal lobe epilepsy
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Published on: 15 May, 2013
Page: [6766 - 6772]