Leptin in Thrombosis and Atherosclerosis

Author(s): Hui Wang, Wei Luo, Daniel T. Eitzman

Journal Name: Current Pharmaceutical Design

Volume 20 , Issue 4 , 2014

Become EABM
Become Reviewer
Call for Editor


A world-wide obesity epidemic is threatening to have a major impact on the prevalence of chronic and acute vascular diseases. In addition to weight loss interventions, which have met with modest success to date, it will be important to understand mechanisms by which obesity promotes vascular disease processes. Studies of leptin, a hormone produced by the adipocyte, have supported the concept that adipocyte-specific products may be mediating some of the vascular risk associated with obesity. This mini-review provides an overview of some of the preclinical studies demonstrating causal relationships between leptin and vascular endpoints. Therapeutic strategies designed to block leptin-mediated signaling events in cells contributing to vascular disease may prove beneficial in obese subjects at risk for vascular complications.

Keywords: Obesity, atherothrombosis, STAT3, PI3K, leptin receptor.

Rights & PermissionsPrintExport Cite as

Article Details

Year: 2014
Published on: 13 February, 2014
Page: [641 - 645]
Pages: 5
DOI: 10.2174/13816128113199990015
Price: $65

Article Metrics

PDF: 30