Abstract
Tuberculosis (TB) is of increasing concern due to the recent emergence and spread of MDR-TB, XDR-TB, TDR-TB and HIV/AIDS pandemic. There is urgent need for novel antitubercular agents which can shorten the treatment duration. Based on isosteric replacement and 3D structural similarity between Linezolid, an oxazolidine antimycobacterial agent, we have designed novel 4-amino-3,5-di(substituted)thiazolin-2(3H)thione/ones, synthesized and evaluated for their antimycobacterial activity on Mycobacterium tuberculosis H37Rv strain. Some of the compounds exhibited potent antimycobacterial activity with MIC values in the range of 1-2 µg/mL. Active compounds were further screened against MDR-TB and XDR-TB strain and found to exhibit promising in vitro activity.
Keywords: Antimycobacterial activity, MDR-TB, thiazolin-thione/ones, XDR-TB.
Anti-Infective Agents
Title:Synthesis and Antitubercular Activity of a Series of Thiazole Derivatives
Volume: 12 Issue: 2
Author(s): Mahesh Chhabria, Shailesh Patel, Sandeep Dholakia, Hardik Mistry and Sweta Patel
Affiliation:
Keywords: Antimycobacterial activity, MDR-TB, thiazolin-thione/ones, XDR-TB.
Abstract: Tuberculosis (TB) is of increasing concern due to the recent emergence and spread of MDR-TB, XDR-TB, TDR-TB and HIV/AIDS pandemic. There is urgent need for novel antitubercular agents which can shorten the treatment duration. Based on isosteric replacement and 3D structural similarity between Linezolid, an oxazolidine antimycobacterial agent, we have designed novel 4-amino-3,5-di(substituted)thiazolin-2(3H)thione/ones, synthesized and evaluated for their antimycobacterial activity on Mycobacterium tuberculosis H37Rv strain. Some of the compounds exhibited potent antimycobacterial activity with MIC values in the range of 1-2 µg/mL. Active compounds were further screened against MDR-TB and XDR-TB strain and found to exhibit promising in vitro activity.
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Cite this article as:
Chhabria Mahesh, Patel Shailesh, Dholakia Sandeep, Mistry Hardik and Patel Sweta, Synthesis and Antitubercular Activity of a Series of Thiazole Derivatives, Anti-Infective Agents 2014; 12 (2) . https://dx.doi.org/10.2174/22113525113119990119
DOI https://dx.doi.org/10.2174/22113525113119990119 |
Print ISSN 2211-3525 |
Publisher Name Bentham Science Publisher |
Online ISSN 2211-3533 |
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