Natural Compounds with Cell Growth Inhibitory Activity in Human Tumor Cell Lines

Author(s): Cristiane M. Cazal, Kantima Choosang, Vanessa Gisele P. Severino, João B. Fernandes, Maria Fátima G. F. da Silva, Paulo C. Vieira, Maria S. J. Nascimento, Gabriela M. Almeida, M. Helena Vasconcelos, Pannee Pakkong, Madalena M. M. Pinto

Journal Name: Anti-Cancer Agents in Medicinal Chemistry
(Formerly Current Medicinal Chemistry - Anti-Cancer Agents)

Volume 13 , Issue 10 , 2013

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Twenty six compounds (coumarins, flavonoids and alkaloids) were evaluated for their ability to inhibit the growth of three human tumor cell lines: breast adenocarcinoma (MCF-7), non-small cell lung cancer (NCI-H460) and melanoma (A375-C5). Three of them [3-hydroxyflavone (6), 2’-hydroxy-3,4,4’,5,6’-pentamethoxychalcone (11), Siderin (20)] were very potent in inhibiting all human tumor cell lines tested. The structure / activity relationship is discussed.

Keywords: Alkaloids, coumarins, flavonoids, tumor cell lines growth inhibitor.

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Article Details

Year: 2013
Published on: 06 December, 2013
Page: [1582 - 1589]
Pages: 8
DOI: 10.2174/1871520613666131125122857
Price: $65

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