Corticosteroids for the Inflammatory Response to Cardiopulmonary Bypass: An Update

Author(s): Jan M. Dieleman

Journal Name: Current Pharmaceutical Design

Volume 19 , Issue 22 , 2013

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Abstract:

Cardiac surgery and cardiopulmonary bypass are associated with an intense activation of the immune system. The systemic inflammatory response that develops in many cardiac surgical patients has the potential to lead to significant postoperative morbidity, and even mortality. Intraoperative corticosteroids are often used as prophylaxis for this systemic inflammatory response. This update provides a review of the existing evidence of the effects of corticosteroids on clinical outcomes after cardiopulmonary bypass, and combines this with emerging evidence from a recently published first large clinical trial of dexamethasone in cardiac surgery.

Keywords: Cardiac surgery, cardiopulmonary bypass, systemic inflammatory response syndrome, corticosteroids, clinical outcomes.

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Article Details

VOLUME: 19
ISSUE: 22
Year: 2013
Page: [3979 - 3991]
Pages: 13
DOI: 10.2174/1381612811319220006
Price: $65

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