4-Aminoquinazoline analogs have been identified as a new class of cancer chemotherapeutic agents with
significant therapeutic efficacy against solid tumors. They are potent and highly selective inhibitors of tyrosine kinase
(TK) and epidermal growth factor receptor (EGFR). Till date various 4-aminoquinazoline analogs have been synthesized
and evaluated for anticancer activity. This review is an attempt to compile the medicinal chemistry of various synthesized
Keywords: 4-Aminoquinazoline, antitumor, apoptosis, cytotoxic, epidermal growth factor receptor, tyrosine kinase.
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Published on: 30 April, 2013
Page: [1177 - 1194]