The hypoxic microenvironment is a clinicopathological characteristic of many diseases, such as rheumatoid arthritis
(RA). As a transcription factor activating the gene expression involved in processes such as cell metabolism and
angiogenesis, hypoxia-inducible factor (HIF) has a central function in adaption to altered oxygen tension and even contributes
to the progression of related diseases. In RA, HIF induces angiogenesis, cell migration, and cartilage destruction,
inhibits the apoptosis of synovial cells and inflammatory cells and initiates glycolysis for energy supply by upregulating
specific protein levels. HIF expression in RA can be regulated in both oxygen-dependent and independent fashions, leading
to the aggravation of this disease. Therefore, HIF is one of the vital RA mediators. Based on the application of HIFtargeted
drug research and development in tumors, HIF is a potential therapeutic target for treating RA.