Magnetic Nanoparticles for Controlling in vitro Fungal Biofilms

Author(s): Mariana Carmen Chifiriuc, Alexandru Mihai Grumezescu, Crina Saviuc, Radu Hristu, Valentina Grumezescu, Coralia Bleotu, Gheorghe Stanciu, Dan Eduard Mihaiescu, Ecaterina Andronescu, Veronica Lazar, Radu Radulescu

Journal Name: Current Organic Chemistry

Volume 17 , Issue 10 , 2013

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Abstract:

Our aim was to investigate the influence of magnetic nanoparticles of Fe3O4/oleic acid – core/shell on the adherence to cellular and inert substrata of clinical fungal using direct and inverted optic microscopy and Confocal Laser Scanning Microscopy (CLSM). The biofilm development ability varied with the tested species (C. albicans>C. tropicalis>C. glabrata>S. cerevisiae>C. krusei>C. famata), its intensity being correlated with early germ tubes production. The magnetite nanoparticles strongly inhibited the mature biofilms development (of 48 and 72 hours) as well as the fungal adherence to the cellular substratum, suggesting that magnetic nanoparticles could be used for obtaining new materials with anti-adherence properties.

Keywords: Core/shell, Fungal biofilm, Fe3O4/oleic acid, Nanofluid, Anti-biofilm.

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Article Details

VOLUME: 17
ISSUE: 10
Year: 2013
Page: [1023 - 1028]
Pages: 6
DOI: 10.2174/1385272811317100004
Price: $58

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