Cardiovascular disease is the leading cause of morbidity and mortality in the Western world. However, it appears that currently
available risk assessment tools often underestimate risk, especially for patients in the intermediate-risk category. Considering the
socioeconomic cost, it is imperative to correctly identify patients in the intermediate-risk category who would benefit from more aggressive
treatment. A plethora of experimental and observational studies provide support that lipoprotein associated phospholipase A2 (Lp-
PLA2) and secretory phospholipases A2 (sPLA2) as well as high sensitivity C-reactive protein (hsCRP) are useful biomarkers of cardiovascular
risk. Particularly, Lp-PLA2) has also been addressed as pharmacological target and we are eagerly awaiting the results of ongoing
phase III clinical trials. In this review we discuss the current literature regarding the pros and cons of these biomarkers.
Keywords: Atherosclerosis, biomarkers, cardiovascular disease, hsCRP, inflammation, Lp-PLA2, PAF-acetylhydrolase, sPLA2.
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