Vitiligo and Allergic Complications from Orthopaedic Joint Implants: The Role of Benzoyl Peroxide

Author(s): Marcel Dudda, Peter Godau, Sammy Al-Benna, Thomas A. Schildhauer, Martin Gothner

Journal Name: Recent Patents on Inflammation & Allergy Drug Discovery
Continued as Recent Advances in Inflammation & Allergy Drug Discovery

Volume 7 , Issue 2 , 2013


Orthopaedic joint implants and osteosynthetic materials are progressively being employed more often. Complications mainly include physical-mechanical problems and infections. Uncommonly, allergic reactions to an alloy metal or a bone cement component have been implicated. Less attention has been paid to the components of bone cement, such as acrylate, catalysers (e.g. peroxide), additive polymers or stabilisers. An important bone cement component is benzoylperoxide (BPO), an initiator of the process enhancement of the bone cement. Vitiligo is an acquired, progressive depigmenting disorder that can induce autoimmune diseases. The occurrence of vitiligo in combination with an infection or allergy is not well described, and this manuscript highlights the possibility of an occurrence of a vitiligo whenever the immunesystem is activated and T-cell activation is observed. The aim of this article was to analyze the diagnosis and management of vitiligo and allergic complications from orthopaedic joint implants due to benzoyl-peroxide and relevant patents.

Keywords: Allergy, benzoyl-peroxide, bone-cement, infection of joint replacement, knee joint replacement, vitiligo.

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Article Details

Year: 2013
Published on: 29 April, 2013
Page: [176 - 182]
Pages: 7
DOI: 10.2174/1872213X11307020009
Price: $65

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