Developments in Synthesis of the Anti-inflammatory Drug, Celecoxib: A Review

Author(s): Vinod Kumar, Kamalneet Kaur, Girish K. Gupta, Akhilesh K. Gupta, Sunil Kumar

Journal Name: Recent Patents on Inflammation & Allergy Drug Discovery

Volume 7 , Issue 2 , 2013

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Celecoxib, a tricyclic compound having pyrazole ring exhibits an excellent level of antiinflammatory action against COX-2 enzymes and some of its analogs act as anticancer and antibacterial agents. Various efficient routes and different improved processes for the synthesis of this drug have already been disclosed in the literature. However, there is a need for further developments in the present scenario of achieving cost effective synthetic technologies to celecoxib with high purity accompanied by excellent yield. Therefore, an effort has been made to summarize briefly the different methods of preparation of Celecoxib with their advantages or disadvantages that have been reported in various patents up to 2013. The present review would be beneficial for scientific community for further developments in the synthetic methodologies for Celecoxib and to explore some novel celecoxib based biologically active agents.

Keywords: Anticancer activity, anti-inflammatory, Celecoxib, COX-2 inhibitor, 4-methylacetophenone, 4- sulphonamidophenyl hydrazine hydrochloride, 4, 4, 4-trifluoro-1-[4-(methylphenyl)] butane-1, 3-dione.

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Article Details

Year: 2013
Published on: 31 March, 2013
Page: [124 - 134]
Pages: 11
DOI: 10.2174/1872213X11307020004
Price: $65

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