Mostly anticancer drugs are given as IV infusions, which result in hypertensive reactions due to formulation
excipients. Their oral bioavailability is poor or variable due to high liver metabolism, poor aqueous solubility, high Pgp
effluxing and macron size. To promote the oral drug delivery of these potential chemotherapeutics, intestinal lymphatic
transport has been recognized as a promising route of drug delivery, especially for nanonized cytotoxic drugs because the
spread of cancer is much early in lymphatics than the vascular system. A little research has been endeavored to deliver
orally, the chemotherapeutics through lymphatic route owing to the complex mechanism involved in their complete absorption.
This review will provide insight into the delivery of lipid based nanocarriers through lymphatic transport system
for enhancing the oral bioavailability of anticancer moieties.
Keywords: Lipids, intestinal lumen, absorption, lymphatic, anticancer.
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