Chalcones are a group of plant-derived polyphenolic compounds belonging to the flavonoids family and
possess a wide variety of cytoprotective and modulatory functions. In this research we tried to review the anticancer effect
of chalcones derivatives and to evaluate new QSARs which will help in the understanding of the role of chalcones and of
their analogs on cancer. Simultaneously a comparative study will be presented. Our QSAR results reveal that: 1) the clog
P (hydrophobicity/hydrophilicity) parameter plays an important part in three QSAR relationships (linear model), 2) the
steric factors such as molar volume MgVol, molar refractivity CMR or the substituents molar refractivity MR (linear) are
important. Electronic effects are comparatively unimportant. These results compared to our previous findings on the
QSAR of anti-proliferative chalcones support primarily the role of bulk.
Keywords: Chalcones, anticancer activity, cytoprotection, QSAR, lipophilicity, steric factors.
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