The evolution of orthologous proteins opens a new era of research where the concepts of orthology and paralogy
have become more and more substantial, as the whole-genome comparison allows their identification in complete genomes.
Functional specificity of proteins is understood to be conserved among orthologs but it shows much more variability
among paralogs. We used this laying claim to identify inter-species interactions based on orthologous protein networks
which are crucial for understanding the evolution of orthologous proteins. We analyzed six classes of enzymatic protein
sequence data using the node degrees of orthologous proteins. The results demonstrated the evolutionary importance of
the fatty acid syntheses and the photosynthetic system in algae. Methods which have successfully exploited network structure
at many different levels of detail are a cornerstone of systems biology.
Keywords: Orthology, Network degree, Enzyme, System biology.
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