A Novel Synthesis of 1,4,7,10-Tetraazacyclododecane by the Tandem Reaction of a Vinylsulfonium Salt

Author(s): Rui Huang, Chunsong Xie, Lin Huang, Jinhua Liu

Journal Name: Letters in Organic Chemistry

Volume 10 , Issue 3 , 2013

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1,4,7,10-Tetraazacyclododecane was synthesized through 4 steps by using easily available diphenylsulfonium triflate as a key annulation reagent. The reaction condition was very mild and the yield was high. After oxidation and hydrolysis, 1,4,7,10-Tetraazacyclododecane, which had been proven to be the pivotal precursor for a wide range of MRI contrast reagents, was produced in an overall yield of 31%.

Keywords: 1, 4, 7, 10-Tetraazacyclododecane, MRI, Tandem Reaction, Vinylsulfonium

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Article Details

Year: 2013
Published on: 31 March, 2013
Page: [195 - 198]
Pages: 4
DOI: 10.2174/1570178611310030009
Price: $65

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