L-Proline as Reusable and Organo Catalyst for the One-Pot Synthesis of Substituted 2-Amino-4H-Chromenes

Author(s): Farahnaz Kargar Behbahani, Mehdi Ghorbani, Mahdieh Sadeghpour, Mohamad Mirzaei

Journal Name: Letters in Organic Chemistry

Volume 10 , Issue 3 , 2013

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L-proline catalyzed one-pot three-component condensation reaction of aromatic aldehydes, malononitrile and naphthols proceeded in EtOH to afford corresponding 2-amino-4H-chromenes in high to excellent yields at reflux conditions. The protocol found to be fairly general and the catalyst was reused in subsequent reactions with consistent activity. Moreover, this method offers several advantages including high to excellent yields of products as well as a simple experimental, work-up procedure and product separation without further purification with column chromatography which makes it a useful and attractive process for the synthesis of these compounds.

Keywords: L-proline, Aldehydes, Malononitrile, naphthols, Multi-Component Reaction, chromenes

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Article Details

Year: 2013
Published on: 31 March, 2013
Page: [191 - 194]
Pages: 4
DOI: 10.2174/1570178611310030008
Price: $65

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