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Letters in Organic Chemistry

Editor-in-Chief

ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

The Synthesis of Enantiomers of 6-tert-Butyl-6-methylmorpholine-2,5- dione Using Wang Resin Supported Mukaiyama Reagent

Author(s): Anna Jakubowska, Joanna Babiuch and Katarzyna Kulig

Volume 10, Issue 3, 2013

Page: [155 - 158] Pages: 4

DOI: 10.2174/1570178611310030002

Price: $65

Abstract

The synthesis of enantiomers of 6-tert-butyl-6-methylmorpholine-2,5-dione (3) using Wang resin supported 2- chloro- or 2-bromo- pyridinium triflate is described. The applied methodology could be considered as an interesting alternative to “classical” one and enables the synthesis of 6-tert-butyl-6-methylmorpholine-2,5-dione with higher yields and the isolation of product (3) is significantly easier.

Keywords: Wang resin supported Mukaiyama reagent, enantiomers of 6-tert-butyl-6-methylmorpholine-2, 5-dione, glycine equivalent.

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