Abstract
Oxidative stress results from the formation of reactive oxygen species (ROS) such as peroxides that cause damage to cell membranes and react with various biomolecules in mammalian cells. The selenoenzyme glutathione peroxidase (GPx) destroys peroxides by catalyzing their reduction to alcohols or water with the stoichiometric reductant glutathione. The effects of oxidative stress have been implicated in a variety of degenerative processes and disease states and for these reasons, there is considerable interest in the discovery of small molecule compounds that could reproduce a GPx-like activity. A review on the most recent acquisition in this area is here reported.
Keywords: Selenium, selenoprots, glutathione, ROS, ebselen
Current Chemical Biology
Title:Selenium Containing Compounds from Poison to Drug Candidates: A Review on the GPx-like Activity
Volume: 7 Issue: 1
Author(s): Claudio Santi, Caterina Tidei, Claudia Scalera, Marta Piroddi and Francesco Galli
Affiliation:
Keywords: Selenium, selenoprots, glutathione, ROS, ebselen
Abstract: Oxidative stress results from the formation of reactive oxygen species (ROS) such as peroxides that cause damage to cell membranes and react with various biomolecules in mammalian cells. The selenoenzyme glutathione peroxidase (GPx) destroys peroxides by catalyzing their reduction to alcohols or water with the stoichiometric reductant glutathione. The effects of oxidative stress have been implicated in a variety of degenerative processes and disease states and for these reasons, there is considerable interest in the discovery of small molecule compounds that could reproduce a GPx-like activity. A review on the most recent acquisition in this area is here reported.
Export Options
About this article
Cite this article as:
Santi Claudio, Tidei Caterina, Scalera Claudia, Piroddi Marta and Galli Francesco, Selenium Containing Compounds from Poison to Drug Candidates: A Review on the GPx-like Activity, Current Chemical Biology 2013; 7 (1) . https://dx.doi.org/10.2174/2212796811307010003
DOI https://dx.doi.org/10.2174/2212796811307010003 |
Print ISSN 2212-7968 |
Publisher Name Bentham Science Publisher |
Online ISSN 1872-3136 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Heat Shock Protein-60 and Risk for Cardiovascular Disease
Current Pharmaceutical Design Rational Autologous Cell Sources For Therapy of Heart Failure - Vehicles and Targets For Gene and RNA Therapies
Current Gene Therapy Selective Serotonin Reuptake Inhibitors in Pregnancy
Current Medicinal Chemistry Plasma Glucose Concentrations and Cardiac Hypertrophy in Essential Hypertension
Current Hypertension Reviews Natural Alkaloids and Diabetes Mellitus: A Review
Endocrine, Metabolic & Immune Disorders - Drug Targets Novel Targets for Cardiac Antiarrhythmic Drug Development
Current Pharmaceutical Design Vitamins B1, B2, B3 and B9 – Occurrence, Biosynthesis Pathways and Functions in Human Nutrition
Mini-Reviews in Medicinal Chemistry MicroRNA in Aging: From Discovery to Biology
Current Genomics Endoplasmic Reticulum Stress as a Novel Therapeutic Target in Heart Diseases
Cardiovascular & Hematological Disorders-Drug Targets Herbal and Traditional Chinese Medicine for the Treatment of Cardiovascular Complications in Diabetes Mellitus
Current Diabetes Reviews Advanced Glycation and ROS: A Link between Diabetes and Heart Failure
Current Vascular Pharmacology Red Cell Distribution Width: A Routinely Available Biomarker with Important Clinical Implications in Patients with Atrial Fibrillation
Current Pharmaceutical Design Persistent Pulmonary Hypertension of the Newborn: Physiology, Hemodynamic Assessment and Novel Therapies
Current Pediatric Reviews Tetracyclic Triterpenoids in Herbal Medicines and their Activities in Diabetes and its Complications
Current Topics in Medicinal Chemistry Endogenous Retroelements in Cellular Senescence and Related Pathogenic Processes: Promising Drug Targets in Age-Related Diseases
Current Drug Targets Cellular Senescence in Cardiovascular Diseases: Potential Age-Related Mechanisms and Implications for Treatment
Current Pharmaceutical Design PET Imaging and Coronary Circulatory Function: Non-Invasive Mechanistic Insights and Cardiovascular Prognosis
Current Cardiology Reviews Coronary CT and the Coronary Calcium Score, the Future of ED Risk Stratification?
Current Cardiology Reviews Cardiac Amyloid - A Hidden Contributor to Cardiac Dysfunction Following Cardiac Surgery: Case Report and Literature Review
Current Cardiology Reviews Phosphorylated and O-GlcNAc Modified IRS-1 (Ser1101) and -2 (Ser1149) Contribute to Human Diabetes Type II
Protein & Peptide Letters