Influence of the Retinal Methyl Groups on Retinal Structure and Dynamics

Author(s): Minoru Sugihara, Ana-Nicoleta Bondar

Journal Name: Current Physical Chemistry

Volume 3 , Issue 2 , 2013

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The light-induced isomerization of the retinal chromophore starts the reaction cycles of retinal proteins. We review and discuss some new computations on the role of the retinal methyl groups in determining the structure, dynamics, and protein interactions of the retinal. The torsional potential of the C11=C12 bond suggests that moderate twisting of this bond can be achieved without a significant energetic cost, allowing for twisted 11-cis geometries to be sampled within the protein environment. The 9- and 13-methyl groups contribute significantly to the geometry and the ground-state torsional properties of the retinal chromophore, but the relative importance of these two methyl groups appears to be different in the dark- vs. the batho-intermediates of visual rhodopsins.

Keywords: Methyl groups, Retinal, Retinal proteins.

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Article Details

Year: 2013
Published on: 31 March, 2013
Page: [211 - 218]
Pages: 8
DOI: 10.2174/1877946811303020011
Price: $25

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